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KMID : 0604520090350020143
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Journal of the Society of Cosmetic Scientists of Korea
2009 Volume.35 No. 2 p.143 ~ p.149
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The Inhibitory Effect of Hydroxycinnamic Acid Derivatives from Corn (Zea may L.) Bran on Melanogenesis
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Kim Mi-Jin
Lim Kyung-Ran
Jung Taek-Kyu
Yoon Kyung-Sup
Choi Sang-Won
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Abstract
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Several hydroxycinnamic acid derivatives, p-coumaric acid, ferulic acid, N,N’-dicoumaroylputrescine (DCP), N-p-coumaroyl-N’-feruloyl-putrescine (CFP), and N,N’-diferuloylputrescine (DFP) were isolated and purified from corn bran. To develop the skin whitening agent, we investigated the effects of hydroxycinnamic acid derivatives from corn bran, on melanogenesis. CFP and DFP inhibited melanin synthesis in a dose dependent manner up to 44.7 ± 6.0 %, and 58.5 ± 3.1 % at a concentration of 50 μg/mL, respectively. The intracellular tyrosinase activity decreased about 42.5 ± 14.6 %, and 9.0 ± 4.4 % at a concentration of 50 μg/mL of CFP and DFP, respectively. Our results suggest that inhibitory effects of hydroxycinnamic acid derivatives on melanogenesis are due to the inhibition of the intracellular tyrosinase activity. These results indicate that these hydroxycinnamic acid derivatives from corn bran may be potential natural skin whitening agents.
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KEYWORD
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corn bran extract, hydroxycinnamic acid derivatives, N, N’-diferuloylputrescine (DFP), N-p-coumaroyl-N’-feruloylputrescine (CFP), melanin
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